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Subthalamic Nucleus Stimulation Does Not Have Any Acute Effects on Verbal Fluency or on Speed of Word Generation in Parkinson's Disease.
Parkinson's Disease ( IF 3.2 ) Pub Date : 2019-10-03 , DOI: 10.1155/2019/6569874
Cyril Atkinson-Clement 1 , Friederike Leimbach 2 , Marjan Jahanshahi 2, 3
Affiliation  

Background. Deep brain stimulation of the subthalamic nucleus (STN-DBS) has been shown to be generally safe from a cognitive perspective, with consistent evidence that the major impact of STN-DBS in Parkinson’s disease (PD) is on verbal fluency. Objective. The aim of this study was first to identify the influence of acute manipulation of STN-DBS in PD on the number and time pattern of word generation on different verbal fluency (VF) tasks, phonemic, switching, and cued switching, and second to determine whether cueing improved VF and if cueing effects interacted with STN-DBS effects. Methods. Parallel versions of these three verbal fluency tasks were completed by 31 patients with Parkinson’s disease who had had bilateral DBS of the STN, twice, with DBS On and Off, with the order counterbalanced across patients. Results. There was no effect of acute STN-DBS on the total number of words generated during verbal fluency. As expected, the number of words generated significantly declined over the six 10-second intervals of the verbal fluency tasks, but this time pattern of word generation was not altered by STN-DBS. External cueing significantly increased the number of words generated relative to an uncued switching verbal fluency task, but the cueing effect on VF was not altered by STN-DBS. Conclusion. In conclusion, (i) acute STN-DBS manipulation did not alter either verbal fluency performance or the time pattern of word generation and (ii) external cueing significantly improved verbal fluency performance both with STN-DBS On and Off.

中文翻译:

丘脑底核刺激对帕金森病患者的语言流畅性或单词生成速度没有任何急性影响。

背景。从认知角度来看,丘脑底核深部脑刺激 (STN-DBS) 已被证明是安全的,一致的证据表明 STN-DBS 对帕金森病 (PD) 的主要影响是对语言流畅性的影响。客观的。本研究的目的首先是确定 PD 中 STN-DBS 的急性操作对不同语言流利性 (VF) 任务、音素、转换和提示转换的单词生成数量和时间模式的影响,其次确定提示是否改善了 VF,以及提示效果是否与 STN-DBS 效果相互作用。方法。这三项言语流利性任务的并行版本由 31 名帕金森病患者完成,这些患者曾接受过 STN 双侧 DBS 两次,DBS开启关闭,顺序在患者之间平衡。结果。急性 STN-DBS 对言语流利度过程中产生的单词总数没有影响。正如预期的那样,在言语流畅性任务的 6 个 10 秒间隔内,生成的单词数量显着下降,但这一次 STN-DBS 没有改变单词生成的模式。相对于无提示切换言语流畅性任务,外部提示显着增加了生成的单词数量,但 STN-DBS 并未改变对 VF 的提示效果。结论。总之,(i)急性 STN-DBS 操作不会改变言语流利度表现或单词生成的时间模式,(ii)外部提示显着提高了 STN-DBS 打开和关闭时的言语流利表现
更新日期:2019-10-03
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