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Assessment of the Therapeutic Effects of Fucoxanthin by Attenuating Inflammation in Ovalbumin-Induced Asthma in an Experimental Animal Model.
Journal of Environmental Pathology, Toxicology and Oncology ( IF 2.4 ) Pub Date : 2019-11-05 , DOI: 10.1615/jenvironpatholtoxicoloncol.2019030154
Xinjun Yang 1 , Gang Guo 2 , Minyan Dang 3 , Lei Yan 2 , Xin Kang 2 , Kunjin Jia 2 , Hong Ren 4
Affiliation  

Asthma has affected more than 300 million people worldwide and is considered one of the most debilitating global public health problems based on a recent statistical report from the Global Initiative for Asthma. Inflammation of the airways leads to the various interrelated mechanisms of innate and adaptive immunity acting mutually with the epithelium of the respiratory organ. Fucoxanthin is an orange or brown pigment which is naturally found in various seaweeds. To the best of our knowledge, there are no scientific claims or evidence of the curative effects of fucoxanthin against asthma. Hence, this present research was designed to investigate the curative activity of fucoxanthin against ovalbumin-induced asthma in a mouse model. Fucoxanthin (50 mg/kg) showed significant (P < 0.001) antiasthma activity. It effectively decreased intracellular secretion of reactive oxygen species and increased antioxidant enzyme activity. Fucoxanthin also decreased inflammatory cytokine markers in bronchoalveolar lavage fluid. Because fucoxanthin showed effective antiasthma activity against ovalbumin-induced asthma in experimental animals, further research on this natural antioxidant could lead to development of a novel drug for the treatment of asthma in humans.

中文翻译:

在实验动物模型中通过减轻卵黄蛋白诱发的哮喘中的炎症来评估岩藻黄质的治疗作用。

哮喘已影响到全球3亿多人,根据全球哮喘倡议的最新统计报告,哮喘被认为是最令人衰弱的全球公共卫生问题之一。气道的炎症导致先天性和适应性免疫的各种相互关联的机制与呼吸器官的上皮相互作用。岩藻黄质是橙色或棕色的色素,天然存在于各种海藻中。据我们所知,目前还没有科学依据或证据表明岩藻黄质具有抗哮喘的疗效。因此,本研究旨在调查岩藻黄质对小鼠模型中卵清蛋白诱导的哮喘的治疗作用。岩藻黄质(50 mg / kg)显示出明显的(P <0.001)抗哮喘活性。它有效地减少了活性氧的细胞内分泌,并增加了抗氧化酶的活性。岩藻黄质还减少了支气管肺泡灌洗液中的炎症细胞因子标记。由于岩藻黄质在实验动物中对卵白蛋白诱导的哮喘表现出有效的抗哮喘活性,因此对该天然抗氧化剂的进一步研究可能会导致开发一种用于治疗人类哮喘的新型药物。
更新日期:2019-11-01
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