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Sensing infection in Drosophila: Toll and beyond.
Seminars in Immunology ( IF 7.8 ) Pub Date : 2004-01-31 , DOI: 10.1016/j.smim.2003.10.008
Dominique Ferrandon 1 , Jean-Luc Imler , Jules A Hoffmann
Affiliation  

Drosophila has evolved a potent immune system that is somewhat adapted to the nature of infections through the selective activation of either one of two NF-kappa B-like signalling pathways, the Toll and IMD (Immune deficiency) pathways. In contrast to the mammalian system, the Toll receptor does not act as a pattern recognition receptor (PRR) but as a cytokine receptor. The sensing of microbial infections is achieved by at least four PRRs that belong to two distinct families: the peptidoglycan recognition proteins (PGRPs) and the Gram-negative binding proteins (GNBPs)/beta-glucan recognition proteins (beta GRPs).

中文翻译:

果蝇中的感官感染:收费及其他。

果蝇已经发展出一种有效的免疫系统,通过选择性激活两种NF-κB样信号通路之一(Toll和IMD(免疫缺陷)通路),某种程度上适应了感染的性质。与哺乳动物系统相反,Toll受体不充当模式识别受体(PRR),而是充当细胞因子受体。至少四个属于两个不同家族的PRR可实现对微生物感染的感知:肽聚糖识别蛋白(PGRP)和革兰氏阴性结合蛋白(GNBP)/β-葡聚糖识别蛋白(βGRP)。
更新日期:2019-11-01
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