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The role of Toll-like receptors in combating mycobacteria.
Seminars in Immunology ( IF 7.8 ) Pub Date : 2004-01-31 , DOI: 10.1016/j.smim.2003.10.005
Stephan R Krutzik 1 , Robert L Modlin
Affiliation  

In the battle against infections with mycobacteria, the body employs components of both the innate and adaptive arms of the immune system. Toll-like receptors (TLRs) mediate the activation of cells of the innate immune system leading to dynamic functions including direct anti-microbial activity, induction of cytokine secretion, triggering dendritic cell maturation, and triggering apoptosis. Furthermore, TLR activation is capable of modulating the adaptive immune response with a bias towards a Th1 T-cell response. However, the activation of TLRs by mycobacteria may also provide a means of immune evasion. Therefore, the modulation of TLR activation can influence the ability to properly destroy invading pathogens such as mycobacteria.

中文翻译:

Toll样受体在对抗分枝杆菌中的作用。

在对抗分枝杆菌感染的斗争中,人体会利用免疫系统先天性和适应性武器的成分。Toll样受体(TLR)介导先天免疫系统细胞的激活,从而导致动态功能,包括直接的抗微生物活性,诱导细胞因子分泌,触发树突状细胞成熟和触发凋亡。此外,TLR激活能够以偏向Th1 T细胞反应的方式调节适应性免疫反应。但是,分枝杆菌对TLR的激活也可能提供逃避免疫的手段。因此,TLR激活的调节可以影响正确破坏入侵的病原体(如分枝杆菌)的能力。
更新日期:2019-11-01
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