Expanded genomic information has driven the discovery of new members of the human Class II family of cytokine receptors (CRF2), which now includes 12 proteins. The corresponding cytokines have been identified, paired with their receptors and initially characterized for function. These cytokines include: a new human Type I IFN, IFN-kappa; molecules related to IL-10 (IL-19, IL-20, IL-22, IL-24, IL-26); and IFN-lambdas (IL-28/29), which have antiviral and cell stimulatory activities reminiscent of Type I IFNs, but act through a distinct receptor. In response to ligand binding, the CRF2 proteins form heterodimers, leading to cytokine-specific cellular responses; these diverse physiological functions are just beginning to be explored. Progress in structural and mutational analysis of ligand-receptor interactions now presents a more reliable framework for understanding receptor-ligand interactions, and for predicting key regions in less well studied members of the CRF2 family. The relationships between the CRF2 proteins will be summarized, as will the progress in identifying patterns of receptor interactions with ligands.

中文翻译：

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II类细胞因子受体（CRF2）家族：受体-配体相互作用的概述和模式。

扩展的基因组信息推动了人类II类细胞因子受体（CRF2）新成员的发现，该成员现已包含12种蛋白质。已经鉴定了相应的细胞因子，与它们的受体配对，并最初对其功能进行了表征。这些细胞因子包括：新型人类I型IFN，IFN-κ；与IL-10相关的分子（IL-19，IL-20，IL-22，IL-24，IL-26）; 和IFN-λ（IL-28 / 29），它们具有抗病毒和细胞刺激的作用，使人联想到I型IFN，但通过不同的受体起作用。响应配体结合，CRF2蛋白形成异二聚体，导致细胞因子特异性细胞反应。这些多样化的生理功能才刚刚开始探索。配体-受体相互作用的结构和突变分析进展现在为理解受体-配体相互作用以及预测研究较少的CRF2家族成员中的关键区域提供了更可靠的框架。将概述CRF2蛋白之间的关系，以及鉴定受体与配体相互作用的模式方面的进展。