Apoptosis in feathers of Smyth line chickens with autoimmune vitiligo.,Journal of Autoimmunity

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Apoptosis in feathers of Smyth line chickens with autoimmune vitiligo.
Journal of Autoimmunity ( IF 12.8 ) Pub Date : 2004-01-08 , DOI: 10.1016/j.jaut.2003.09.006
X Wang ₁ , G F Erf

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Vitiligo is an acquired dermatological disorder characterized by a loss of epidermal melanocytes resulting in depigmentation of the skin. Mechanisms underlying the destruction of melanocytes in vitiligo remain unclear. An animal model to study spontaneously occurring autoimmune vitiligo is the mutant Smyth line (SL) of chickens. This investigation was designed to determine whether the pathogenesis of depigmentation in Smyth line chicken vitiligo (SLV) involves an apoptotic mechanism. Terminal deoxynucleotide transferase-mediated fluorescein-dUTP nick end labeling (TUNEL) was used to detect in situ cell apoptosis in cryostat sections of 2-week-old regenerating feathers. Two-week-old regenerating feathers were obtained from SL chickens and their normally pigmented controls including the parental Brown line (BL) and Light Brown Leghorn (LBL) chickens at 6, 8, 10 and 12 weeks of age. In feathers from vitiliginous SL chickens, the number of TUNEL+ cells was significantly (P

中文翻译：

具有自身免疫性白癜风的史密斯系鸡羽毛中的细胞凋亡。

白癜风是一种获得性皮肤病，其特征是表皮黑素细胞减少导致皮肤脱色。白癜风中黑素细胞破坏的潜在机制尚不清楚。研究自发性自身免疫性白癜风的动物模型是鸡的突变史密斯系（SL）。本研究旨在确定史密斯系鸡白癜风（SLV）中色素沉着的发病机制是否涉及凋亡机制。末端脱氧核苷酸转移酶介导的荧光素-dUTP缺口末端标记（TUNEL）用于检测2周龄再生羽毛的低温恒温器切片中的原位细胞凋亡。从SL鸡及其正常着色的对照（包括6、8、10和12周龄的亲本棕线（BL）和浅棕来克亨鸡（LBL）鸡）中获得了两周龄的再生羽毛。在白质SL鸡的羽毛中，TUNEL +细胞的数量显着（P

更新日期：2019-11-01

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