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The lung as a privileged site for the beneficial actions of PGE2.
Trends in Immunology ( IF 16.8 ) Pub Date : 2003-12-31 , DOI: 10.1016/j.it.2003.11.001
Carlo Vancheri 1 , Claudio Mastruzzo , Maria Angela Sortino , Nunzio Crimi
Affiliation  

Prostaglandin E2 (PGE2) is commonly considered a potent proinflammatory mediator and is involved in several inflammatory diseases. In the lung, as opposed to many other parts of the body, PGE2 has a role in limiting the immune-inflammatory response as well as tissue repair processes. Understanding the full implications of the regulatory role of PGE2 and how beneficial processes, such as inflammation and tissue repair, become dysregulated to the point of causing disease, might disclose new perspectives in the treatment of pulmonary diseases.

中文翻译:

肺是PGE2有益作用的优先部位。

前列腺素E2(PGE2)通常被认为是有效的促炎介质,并参与多种炎症疾病。与身体的许多其他部位相反,PGE2在肺中具有限制免疫炎症反应以及组织修复过程的作用。了解PGE2调节作用的全部含义以及有益过程(例如炎症和组织修复)如何失调至引起疾病的程度,可能会揭示治疗肺部疾病的新观点。
更新日期:2019-11-01
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