Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic reticulum (ER), the site of antibody biosynthesis. Recent discoveries have provided insights into how this expansive secretory machinery is built, equipped and maintained. The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the ER, regulates the expression and activity of X-box binding protein 1, a transcription factor required for plasma-cell development. The UPR pathway therefore senses conditions in the ER--the very compartment where antibodies are formed--and directs events required for humoral immunity.

中文翻译：

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压力过大的B细胞？浆细胞分化和未折叠的蛋白质反应。

浆细胞作为工厂运作，制造大量Ig重链和轻链并将其组装成功能性抗体。成品以惊人的效率运出。高速率抗体分泌所必需的机制的主要组成部分是复杂的内质网（ER），即抗体生物合成的位点。最近的发现提供了有关如何构建，配备和维护这种广泛的分泌机具的见解。未折叠的蛋白质反应（UPR）途径是一种由ER引起的应激诱导信号传导级联，它调节X-box结合蛋白1（浆细胞发育所需的转录因子）的表达和活性。