Remarkable advances in our knowledge of the genome sequence have led to the creation of databases that afford the opportunity to discover genes based on the presence of specific sequence motifs. The application of this strategy to the identification of proteins in families of immunological interest has had a visible impact on the sizes of the interleukin 1/18 and the CD28/B7 costimulatory molecule families, among many others. This accelerated pace of discovery presents a new challenge to match the rate of discovery with biological understanding of the functions of these extended protein families.

中文翻译：

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信息学与免疫系统：不断增长的IL-1和B7蛋白家族。

我们对基因组序列的了解取得了显着进展，导致创建了数据库，这些数据库提供了基于特定序列基序的存在来发现基因的机会。该策略在免疫学目的家族蛋白鉴定中的应用对白介素1/18和CD28 / B7共刺激分子家族的大小产生了明显影响。这种加快的发现速度提出了新的挑战，以使发现速率与这些扩展蛋白家族功能的生物学理解相匹配。