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Enzymes of triacylglycerol synthesis and their regulation.
Progress in Lipid Research ( IF 13.6 ) Pub Date : 2003-12-05 , DOI: 10.1016/s0163-7827(03)00051-1 Rosalind A Coleman 1 , Douglas P Lee
Progress in Lipid Research ( IF 13.6 ) Pub Date : 2003-12-05 , DOI: 10.1016/s0163-7827(03)00051-1 Rosalind A Coleman 1 , Douglas P Lee
Affiliation
Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions and the factors that regulate triacylglycerol biosynthesis. In the last few decades, in part due to advances in technology and the wide availability of nucleotide and amino acid sequences, we have made enormous strides in our understanding of these enzymes at the molecular level. In many cases, sequence information obtained from lipid biosynthetic enzymes of prokaryotes and yeast has provided the means to search the genomic and expressed sequence tag databases for mammalian homologs and most of the genes have now been identified. Surprisingly, multiple isoforms appear to catalyze the same chemical reactions, suggesting that each isoform may play a distinct functional role in the pathway of triacylglycerol and phospholipid biosynthesis. This review focuses on the de novo biosynthesis of triacylglycerol in eukaryotic cells, the isoenzymes that are involved, their subcellular locations, how they are regulated, and their putative individual roles in glycerolipid biosynthesis.
中文翻译:
三酰基甘油合成酶及其调控。
自从1950年代阐明了甘油脂的生物合成途径以来,已经获得了有关催化脂质生物合成反应的酶以及调节三酰基甘油生物合成的因素的大量知识。在过去的几十年中,部分由于技术的进步以及核苷酸和氨基酸序列的广泛可用性,我们在分子水平上对这些酶的理解有了长足的进步。在许多情况下,从原核生物和酵母的脂质生物合成酶获得的序列信息为搜索哺乳动物同源物的基因组和表达序列标签数据库提供了手段,并且现已鉴定出大多数基因。令人惊讶的是,多种同工型似乎催化相同的化学反应,提示每种同工型可能在甘油三酯和磷脂的生物合成途径中发挥独特的功能。这篇综述集中在真核细胞中三酰基甘油的从头生物合成,所涉及的同工酶,它们的亚细胞位置,它们的调控方式以及它们在甘油脂生物合成中的假定的个体作用。
更新日期:2019-11-01
中文翻译:
三酰基甘油合成酶及其调控。
自从1950年代阐明了甘油脂的生物合成途径以来,已经获得了有关催化脂质生物合成反应的酶以及调节三酰基甘油生物合成的因素的大量知识。在过去的几十年中,部分由于技术的进步以及核苷酸和氨基酸序列的广泛可用性,我们在分子水平上对这些酶的理解有了长足的进步。在许多情况下,从原核生物和酵母的脂质生物合成酶获得的序列信息为搜索哺乳动物同源物的基因组和表达序列标签数据库提供了手段,并且现已鉴定出大多数基因。令人惊讶的是,多种同工型似乎催化相同的化学反应,提示每种同工型可能在甘油三酯和磷脂的生物合成途径中发挥独特的功能。这篇综述集中在真核细胞中三酰基甘油的从头生物合成,所涉及的同工酶,它们的亚细胞位置,它们的调控方式以及它们在甘油脂生物合成中的假定的个体作用。