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Synthesis and conformational analysis of arabinofuranosides, galactofuranosides and fructofuranosides.
Current Opinion in Chemical Biology ( IF 7.8 ) Pub Date : 2003-12-04 , DOI: 10.1016/j.cbpa.2003.10.005
Todd L Lowary 1
Affiliation  

Many microorganisms produce biologically important polysaccharides containing galactofuranosyl, arabinofuranosyl and/or fructofuranosyl residues. Recent interest in identifying antibiotics that act by inhibiting the biosynthesis of these glycans has resulted in the development of new and efficient methods for the assembly of oligosaccharides containing furanose residues. In general, it is now possible to synthesize any furanose-containing oligosaccharide with reasonable efficiency. In conjunction with these synthetic investigations, an increasing number of studies have probed the conformation of furanose rings, and a solid appreciation of the conformational preferences of key furanoside ring systems is now available.

中文翻译:

阿拉伯呋喃糖苷,半乳​​糖呋喃糖苷和果糖呋喃糖苷的合成和构象分析。

许多微生物产生含有半乳糖呋喃糖基,阿拉伯呋喃糖基和/或果呋喃糖基残基的生物学上重要的多糖。最近对鉴定通过抑制这些聚糖的生物合成起作用的抗生素的兴趣已导致开发新的有效方法来组装含有呋喃糖残基的寡糖。通常,现在有可能以合理的效率合成任何含呋喃糖的寡糖。与这些综合研究相结合,越来越多的研究已经探究了呋喃糖环的构象,并且现在可以对关键呋喃糖苷环系统的构象偏好进行深入的了解。
更新日期:2019-11-01
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