Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.

中文翻译：

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PNA-肽缀合物的合成发展。

自从1990年代初期发现肽核酸（PNA）作为DNA模仿物以来，人们一直致力于将其用作反义和抗原探针。为了进一步增强其性能，已将PNA与多种效应分子缀合。其中，通常衍生自功能蛋白的小肽片段能够将其特定特性传递给结合物。