Efforts to control HIV infection have led to the development of several antiretroviral drugs that can limit virus replication, however, these therapies do not offer a long-term solution to the infection. We can learn a great deal from HIV-infected individuals who have lived for more than ten years and remain healthy without receiving antiviral drugs. These long-term survivors or long-term non-progressors have an immune system that can control HIV infection. A major component of this immune response is innate immunity, particularly the CD8(+) cell antiviral non-cytotoxic response (CNAR), mediated by a novel CD8(+) cell antiviral factor (CAF). The characteristics of CNAR and CAF will be described and progress made toward identifying CAF will be reviewed. These studies have uncovered several potentially important natural anti-HIV factors and their relationship to the originally described CAF is considered.

中文翻译：

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搜索CD8 +细胞抗HIV因子（CAF）。

控制HIV感染的努力已导致开发了几种可以限制病毒复制的抗逆转录病毒药物，但是，这些疗法并未为感染提供长期解决方案。我们可以从已感染艾滋病毒的人那里学到很多东西，这些人已经生活了十多年并且在没有接受抗病毒药物的情况下保持健康。这些长期存活者或长期非进展者具有可以控制HIV感染的免疫系统。这种免疫应答的主要成分是先天免疫，尤其是由新型CD8（+）细胞抗病毒因子（CAF）介导的CD8（+）细胞抗病毒非细胞毒性应答（CNAR）。将描述CNAR和CAF的特征，并将回顾识别CAF的进展。