Control of fertility constitutes a global health issue, as overpopulation and unintended pregnancy have both major personal and societal impact. Although the contraceptive revolution in the 1960s following the development of hormonal-based oral contraceptives for women has had a major impact on societal dynamics in several cultures, little product innovation has occurred since then. One solution to this global health issue lies in the development of new and innovative contraceptives for both women and men, the goal of which is to provide a range of options for people at all stages and walks of life. Currently, three options for male-based contraception exist (i.e. withdrawal, condoms and vasectomy), and these are acknowledged as woefully inadequate. Introduction of new forms of male contraception based on both hormonal and non-hormonal paradigms are wanted and needed; this need is now becoming recognized by both the public and private sectors. New and innovative products will come from our knowledge of the unique physiology and genetics of reproduction, as well as by exploiting existing and future genomics, proteomics and protein network platforms.

中文翻译：

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男性避孕药的发展现状和未来方向。

由于人口过剩和意外怀孕对个人和社会都产生重大影响，因此控制生育是全球性的健康问题。尽管在1960年代女性开发了基于激素的口服避孕药之后，避孕革命对几种文化的社会动态产生了重大影响，但此后几乎没有产品创新。解决这一全球健康问题的方法之一是开发针对男性和女性的新型和创新型避孕药具，其目标是为各个阶段和各行各业的人们提供一系列选择。当前，存在基于男性的避孕的三种选择（即戒断，避孕套和输精管切除术），这些选择被认为是严重不足的。迫切需要基于荷尔蒙和非荷尔蒙范式的新型男性避孕方法；现在，公共和私营部门都已意识到这种需求。新产品和创新产品将来自我们对生殖的独特生理学和遗传学的了解，以及通过利用现有和未来的基因组学，蛋白质组学和蛋白质网络平台。