Shikimic acid is a high valued compound used as a key starting material for the synthesis of the neuramidase inhibitor GS4104, which was developed under the name Tamiflu for treatment of antiviral infections. An excellent alternative to the isolation of shikimic acid from fruits of the Illicium plant is the fermentative production by metabolic engineered microorganisms. Fermentative production of shikimic acid was most successfully carried out by rational designed Escherichia coli strains by blocking the aromatic amino acid pathway after the production of shikimic acid. An alternative is to produce shikimic acid as a result of dephosphorylation of shikimate-3-phosphate. Engineering the uptake of carbon, the regulatory circuits, central metabolism and the common aromatic pathway including shikimic acid import that have all been targeted to effect higher productivities and lower by-product formation are discussed.

中文翻译：

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sh草酸微生物生产的代谢工程。

ki草酸是一种高价值的化合物，用作合成神经酰胺酶抑制剂GS4104的关键原料，该药物以Tamiflu的名称开发，用于治疗抗病毒感染。从八角茴香植物的果实中分离of草酸的一种极好的替代方法是通过代谢工程微生物发酵生产。合理设计的大肠杆菌菌株在blocking草酸生产后阻断芳香族氨基酸途径，最成功地进行了iki草酸的发酵生产。一种替代方法是由于sh草酸酯-3-磷酸的去磷酸化而产生sh草酸。设计碳的吸收，调节电路，