Genetic dissection of human systemic lupus erythematosus (SLE) has been under intense studies during the past decade. Although the complexity inherent to polygenic, multifactorial diseases is challenging, several new insights have been obtained in the past several years using linkage and association studies of families containing SLE patients as well as case-control studies of populations. In addition, recent advances in our understanding of the human genome and emerging technology have been providing new tools in analyses of complex traits, such as SLE. An overview of our current understanding of the genetic basis of SLE and a brief review of findings of linkage and association studies are described here.

中文翻译：

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人类系统性红斑狼疮的遗传学。

在过去的十年中，对人类系统性红斑狼疮（SLE）的遗传解剖进行了深入研究。尽管多基因，多因素疾病固有的复杂性具有挑战性，但是在过去几年中，通过对包含SLE患者的家庭的联系和关联研究以及人群的病例对照研究，已经获得了一些新的见解。此外，我们对人类基因组和新兴技术的了解的最新进展为分析复杂特征（例如SLE）提供了新工具。本文概述了我们对SLE遗传基础的当前理解，并简要回顾了连锁和关联研究的发现。