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Cytokine-mediated inflammation in acute lung injury.
Cytokine & Growth Factor Reviews ( IF 13.0 ) Pub Date : 2003-10-18 , DOI: 10.1016/s1359-6101(03)00059-5
Richard B Goodman 1 , Jérôme Pugin , Janet S Lee , Michael A Matthay
Affiliation  

Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill patients. There is considerable experimental and clinical evidence that pro- and anti-inflammatory cytokines play a major role in the pathogenesis of inflammatory-induced lung injury from sepsis, pneumonia, aspiration, and shock. A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients with ALI. Interestingly, this protective ventilatory strategy was associated with a marked reduction in the number of neutrophils and the concentration of pro-inflammatory cytokines released into the airspaces of the injured lung. Further research is needed to establish the contribution of cytokines to both the pathogenesis and resolution of ALI.

中文翻译:

细胞因子介导的急性肺损伤炎症。

临床急性肺损伤(ALI)是危重患者急性呼吸衰竭的主要原因。有大量的实验和临床证据表明,促炎和抗炎细胞因子在由脓毒症,肺炎,误吸和休克引起的炎症性肺损伤的发病机理中起主要作用。最近的一项多中心临床试验发现,肺部保护通气策略可将ALI患者的死亡率降低22%。有趣的是,这种保护性通气策略与中性粒细胞数量的显着减少和释放到受伤肺空域的促炎性细胞因子浓度有关。需要进一步的研究来确定细胞因子对ALI的发病机制和分辨率的贡献。
更新日期:2019-11-01
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