Autoantibodies can be detected in autoimmune diseases with a long prodromal phase and may serve as early indicators of disease activity. Autoantibody-based screening methods are therefore potent tools for the identification of target antigens. The SEREX method (serological identification of antigens by recombinant expression cloning) has been developed for the serological definition of immunogenic tumor antigens. Recent studies indicate that the SEREX approach may also be utilized for the analysis of complex immune responses involved in autoimmune diseases.

中文翻译：

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通过SEREX显微镜观察到的自身免疫性。

自身抗体可以在前驱期较长的自身免疫性疾病中检测到，并且可以作为疾病活动的早期指标。因此，基于自身抗体的筛选方法是用于鉴定靶抗原的有效工具。已开发出SEREX方法（通过重组表达克隆进行血清学鉴定）来确定免疫原性肿瘤抗原的血清学。最近的研究表明，SEREX方法也可用于分析自身免疫性疾病涉及的复杂免疫反应。