当前位置: X-MOL 学术Autoimmun. Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Autoantigenicity of nucleolar complexes.
Autoimmunity Reviews ( IF 13.6 ) Pub Date : 2003-10-11 , DOI: 10.1016/s1568-9972(03)00029-6
Tim J M Welting 1 , Reinout Raijmakers , Ger J M Pruijn
Affiliation  

Autoantibodies targeting nucleolar autoantigens (ANoA) are most frequently found in sera from patients with systemic sclerosis (SSc, also designated scleroderma) or with SSc overlap syndromes. During the last decade an extensive number of nucleolar components have been identified and this allowed a more detailed analysis of the identity of nucleolar autoantigens. This review intends to give an overview of the molecular composition of the major (families of) autoantigenic nucleolar complexes, to provide some insight into their functions and to summarise the data concerning their autoantigenicity.

中文翻译:

核仁复合物的自身抗原性。

靶向核仁自身抗原(ANoA)的自身抗体最常见于患有系统性硬化症(SSc,也称为硬皮病)或SSc重叠综合征的患者的血清中。在过去的十年中,已经鉴定出大量的核仁成分,这使得可以对核仁自身抗原的身份进行更详细的分析。本文旨在概述主要(家族)自身抗原核仁复合物的分子组成,以深入了解其功能并总结有关自身抗原性的数据。
更新日期:2019-11-01
down
wechat
bug