当前位置:
X-MOL 学术
›
Ageing Res. Rev.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Monitoring the ubiquitin/proteasome system in conformational diseases.
Ageing Research Reviews ( IF 13.1 ) Pub Date : 2003-10-03 , DOI: 10.1016/s1568-1637(03)00031-x Kristina Lindsten 1 , Nico P Dantuma
Ageing Research Reviews ( IF 13.1 ) Pub Date : 2003-10-03 , DOI: 10.1016/s1568-1637(03)00031-x Kristina Lindsten 1 , Nico P Dantuma
Affiliation
Controlled proteolysis of regulatory or aberrant proteins by the ubiquitin/proteasome system is indispensable for cell viability. Conformational diseases such as Alzheimer's, Parkinson's and Huntington's disease are characterised by the accumulation of misfolded or aggregation-prone proteins. Since these proteins are typical substrates of the ubiquitin/proteasome system, it is not surprising that various models propose impairment of this system as a contributing factor to the pathology of conformational disorders. The complex nature of the ubiquitin/proteasome system and its universal role in cell physiology however turns evaluation of these attractive hypotheses into a major challenge. Several reporter substrates for the ubiquitin/proteasome system have recently been developed to facilitate functional studies of the system in living cells. In this review, we will discuss these new tools as well as the proteins associated with conformational disease that have been studied with these reporters.
中文翻译:
监测构象疾病中的泛素/蛋白酶体系统。
泛素/蛋白酶体系统对调节蛋白或异常蛋白的控制蛋白水解对于细胞活力是必不可少的。诸如阿尔茨海默氏症,帕金森氏症和亨廷顿氏症等构象性疾病的特征是蛋白质折叠错误或易于聚集的现象。由于这些蛋白质是泛素/蛋白酶体系统的典型底物,因此,各种模型都提出将该系统的损害作为构象性疾病病理的一个重要因素就不足为奇了。泛素/蛋白酶体系统的复杂性质及其在细胞生理学中的普遍作用使对这些有吸引力的假设的评估成为一项重大挑战。最近已经开发了泛素/蛋白酶体系统的几种报道分子底物,以促进该系统在活细胞中的功能研究。在这篇综述中,我们将讨论这些新工具以及已经与这些报道者一起研究的与构象性疾病相关的蛋白质。
更新日期:2019-11-01
中文翻译:
监测构象疾病中的泛素/蛋白酶体系统。
泛素/蛋白酶体系统对调节蛋白或异常蛋白的控制蛋白水解对于细胞活力是必不可少的。诸如阿尔茨海默氏症,帕金森氏症和亨廷顿氏症等构象性疾病的特征是蛋白质折叠错误或易于聚集的现象。由于这些蛋白质是泛素/蛋白酶体系统的典型底物,因此,各种模型都提出将该系统的损害作为构象性疾病病理的一个重要因素就不足为奇了。泛素/蛋白酶体系统的复杂性质及其在细胞生理学中的普遍作用使对这些有吸引力的假设的评估成为一项重大挑战。最近已经开发了泛素/蛋白酶体系统的几种报道分子底物,以促进该系统在活细胞中的功能研究。在这篇综述中,我们将讨论这些新工具以及已经与这些报道者一起研究的与构象性疾病相关的蛋白质。