Physical principles of photon correlation spectroscopy (PCS), mathematical treatment of the PCS data (converting autocorrelation functions to distribution functions or average characteristics), and PCS applications to study proteins and other biomacromolecules in aqueous media are described and analysed. The PCS investigations of conformational changes in protein molecules, their aggregation itself or in consequence of interaction with other molecules or organic (polymers) and inorganic (e.g. fumed silica) fine particles as well as the influence of low molecular compounds (surfactants, drugs, salts, metal ions, etc.) reveal unique capability of the PCS techniques for elucidation of important native functions of proteins and other biomacromolecules (DNA, RNA, etc.) or microorganisms (Escherichia coli, Pseudomonas putida, Dunaliella viridis, etc.). Special attention is paid to the interaction of proteins with fumed oxides and the impact of polymers and fine oxide particles on the motion of living flagellar microorganisms analysed by means of PCS.

中文翻译：

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蛋白质的光子相关光谱研究。

描述并分析了光子相关光谱（PCS）的物理原理，PCS数据的数学处理（将自相关函数转换为分布函数或平均特征）以及PCS在研究水性介质中蛋白质和其他生物大分子中的应用。PCS研究蛋白质分子的构象变化，其本身的聚集或与其他分子或有机（聚合物）和无机（例如气相二氧化硅）微粒相互作用的结果，以及低分子化合物（表面活性剂，药物，盐）的影响，金属离子等）揭示了PCS技术独特的能力，可阐明蛋白质和其他生物大分子（DNA，RNA等）或微生物（大肠杆菌，恶臭假单胞菌，杜氏藻等）的重要天然功能。