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The biology of IL-12: coordinating innate and adaptive immune responses.
Cytokine & Growth Factor Reviews ( IF 13.0 ) Pub Date : 2003-09-02 , DOI: 10.1016/s1359-6101(03)00043-1
Wendy T Watford 1 , Masato Moriguchi , Akio Morinobu , John J O'Shea
Affiliation  

Cytokines play critical roles in regulating all aspects of immune responses, including lymphoid development, homeostasis, differentiation, tolerance and memory. Interleukin (IL)-12 is especially important because its expression during infection regulates innate responses and determines the type and duration of adaptive immune response. IL-12 induces interferon-gamma (IFN-gamma) production by NK, T cells, dendritic cells (DC), and macrophages. IL-12 also promotes the differentiation of naïve CD4+ T cells into T helper 1 (Th1) cells that produce IFN-gamma and aid in cell-mediated immunity. As IL-12 is induced by microbial products and regulates the development of adaptive immune cells, IL-12 plays a central role in coordinating innate and adaptive immunity. IL-12 and the recently identified cytokines, IL-23 and IL-27, define a family of related cytokines that induce IFN-gamma production and promote T cell expansion and proliferation.

中文翻译:

IL-12的生物学特性:协调先天性和适应性免疫反应。

细胞因子在调节免疫反应的各个方面都起着至关重要的作用,包括淋巴发育,体内平衡,分化,耐受性和记忆力。白介素(IL)-12尤其重要,因为其在感染过程中的表达调节先天性反应并确定适应性免疫反应的类型和持续时间。IL-12诱导NK,T细胞,树突状细胞(DC)和巨噬细胞产生干扰素-γ(IFN-γ)。IL-12还促进幼稚的CD4 + T细胞分化为T辅助1(Th1)细胞,从而产生IFN-γ并有助于细胞介导的免疫。由于IL-12由微生物产物诱导并调节适应性免疫细胞的发育,因此IL-12在协调先天和适应性免疫中起着核心作用。IL-12和最近发现的细胞因子IL-23和IL-27,
更新日期:2019-11-01
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