Background: Epstein-Barr virus (EBV) infection and microRNA-155 (miR-155) are considered etiological factors that contribute to nasopharyngeal carcinoma (NPC). The regulation of miR-155 expression induced by EBV infection has been reported to be important in NPC tumorigenesis. Aims: This study was designed to explore the relationships among the expression levels of miR-155, LMP-1 (latent membrane protein-1), and LMP-2 (latent membrane protein-2) in tumor and nontumor specimens of Vietnamese NPC patients. The study was also designed to investigate the association between miR-155 expression and LMP-1 and LMP-2 expression in Vietnamese NPC patients. Materials and Methods: Ninety-three NPC biopsy samples and 100 noncancerous swab specimens were collected from patients and analyzed by real-time reverse transcriptase polymerase chain reaction. Results: LMP-1, LMP2, and miR-155 were significantly upregulated in 76.34%, 67.74%, and 75.27% of NPC samples, respectively, with decreased expression observed in the control group (p < 0.0001). Moreover, the statistical analysis showed that there was a close association between LMP-1 and LMP-2 expression and miR-155 expression in the NPC samples. Conclusion: miR-155 expression was upregulated and significantly associated with the expression of LMP-1 and LMP-2, in Vietnamese NPC cases.

中文翻译：

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LMP-1，LMP-2和miR-155表达之间的关联作为鼻咽癌患者潜在的生物标志物：越南的一项病例/对照研究。

背景：爱泼斯坦-巴尔病毒（EBV）感染和microRNA-155（miR-155）被认为是导致鼻咽癌（NPC）的病因。据报道，由EBV感染诱导的miR-155表达的调节在NPC肿瘤发生中很重要。目的：本研究旨在探讨越南NPC患者肿瘤和非肿瘤标本中miR-155，LMP-1（潜伏膜蛋白-1）和LMP-2（潜伏膜蛋白-2）的表达水平之间的关系。 。该研究还旨在调查越南NPC患者中miR-155表达与LMP-1和LMP-2表达之间的关联。材料与方法：收集患者的93份NPC活检样本和100份非癌拭子样本，并通过实时逆转录酶聚合酶链反应进行分析。结果：LMP-1，LMP2和miR-155在NPC样品中分别显着上调，分别为76.34％，67.74％和75.27％，在对照组中观察到表达降低（p <0.0001）。而且，统计分析表明，在NPC样品中LMP-1和LMP-2表达与miR-155表达之间存在密切的联系。结论：越南NPC患者miR-155表达上调，并与LMP-1和LMP-2表达显着相关。