4-hydroxy-2-nonenal (HNE) activates a variety of signaling pathways. We have recently evaluated the effect of oxidized fatty acid metabolites on cyclooxygenase-2 (COX-2) induction in rat liver epithelial RL34 cells and found that, among the compounds tested, HNE most dramatically induced COX-2. A p38 mitogen-activated protein kinase (p38 MAPK) pathway has been shown to play a key role in the mechanism of the HNE-induced COX-2 expression. It appears that the HNE-induced activation of p38 MAPK leads to the stabilization of COX-2 mRNA.

中文翻译：

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4-羟基-2-壬烯醛作为COX-2诱导剂。

4-羟基-2-壬烯醛（HNE）激活多种信号通路。我们最近评估了氧化脂肪酸代谢产物对大鼠肝上皮RL34细胞中环氧合酶2（COX-2）的诱导作用，发现在所测试的化合物中，HNE最能诱导COX-2。已显示p38促分裂原活化蛋白激酶（p38 MAPK）途径在HNE诱导的COX-2表达的机制中起关键作用。看来，HNE诱导的p38 MAPK激活导致COX-2 mRNA的稳定。