During embryonic development, the array of vastly different neuronal types that are incorporated into the functional architecture of the mature neuroretina derives from a common population of multipotent retinal progenitor cells (RPCs). Retinogenesis proceeds in a precise chronological order, with the seven principal cell classes generated in successive phases. Cell biological experiments established that this histogenetic order, at least in part, reflects intrinsic changes within the RPC pool. In recent years a number of molecules controlling various aspects of cell fate specification from RPCs have been identified. However, few attempts have been made to integrate previous concepts that emerged from cell biological studies and more recent results based on molecular genetic experiments. This review aims at providing an overview of recent advances in our understanding of the cellular and molecular mechanisms underlying retinal neuronal diversification, with a particular focus on cell-intrinsic factors.

中文翻译：

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视网膜神经元多样化的转录控制。

在胚胎发育过程中，并入成熟神经视网膜功能结构的神经元类型差异很大，它们来自共同的多能视网膜祖细胞（RPC）群体。视网膜发生以精确的时间顺序进行，七个主要的细胞类别在连续的阶段中产生。细胞生物学实验确定，这种组织遗传顺序至少部分反映了RPC库内的内在变化。近年来，已发现许多控制RPC调控细胞命运规范各个方面的分子。但是，很少有人尝试将细胞生物学研究中出现的先前概念与基于分子遗传实验的最新结果进行整合。