This review focuses on several aspects of humoral immunologic defence of the ocular surface and intraocular compartment. Secretory IgA (sIgA) is a major component of lacrimal fluid and contributes to the first line of defence against infection of the ocular surface. Recent findings show that part of the lacrimal gland (LG) IgA repertoire consists of so-called natural IgA antibodies. How B cells responsible for these natural IgA antibodies are distributed to effector mucosal sites like the LG is not known. Extensive data are now available on the regionalization of mucosal IgA responses in murine gut, involving peritoneal B cells, the prototypic natural antibody producing cells. By comparing elaborate experiments done in mice with the much less extensive data on the LG, it becomes clear that this gland is a unique, but poorly investigated effector organ of the mucosal immune system. In addition to the humoral immune response at the surface of the eye, the production of antibodies within the ocular compartment also has several fascinating features. The detection of pathogen-specific antibodies in intraocular fluid (IOF) of uveitis patients is accepted as a diagnostic tool, but the specificity of these intraocular antibodies was not investigated in much detail. Recent data however, demonstrate that even antibodies recognizing the same antigen in both serum and IOF still differ in the epitopes they recognize. This reveals that the intraocular compartment largely determines its own antibody profile in the defence against intra-ocular pathogens. Several models as to how an exclusive intra-ocular B cell repertoire may be generated are presented.

中文翻译：

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在健康和疾病方面的眼部体液免疫反应。

这篇综述集中在眼表和眼内腔的体液免疫防御的几个方面。分泌型IgA（sIgA）是泪液的主要成分，有助于抵御眼表感染的第一道防线。最近的发现表明，泪腺（LG）IgA组成部分的一部分由所谓的天然IgA抗体组成。尚不清楚负责这些天然IgA抗体的B细胞如何分布到LG效应粘膜部位。现在可获得关于鼠肠中粘膜IgA应答区域的广泛数据，涉及腹膜B细胞，即原型天然抗体产生细胞。通过将小鼠进行的精心设计的实验与LG上数据少得多的数据进行比较，可以清楚地看到该腺体是唯一的，但对粘膜免疫系统的效应器官研究不足。除了眼表面的体液免疫反应外，眼室内抗体的产生还具有一些令人着迷的特征。葡萄膜炎患者眼内液（IOF）中病原体特异性抗体的检测被认为是诊断工具，但是这些眼内抗体的特异性并未得到详细研究。然而，最近的数据表明，即使在血清和IOF中识别相同抗原的抗体在其识别的表位上仍然存在差异。这表明眼内区隔很大程度上决定了其自身的抗体谱，以防御眼内病原体。提出了几种有关如何生成眼内B细胞库的模型。