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The TNF family members BAFF and APRIL: the growing complexity.
Cytokine & Growth Factor Reviews ( IF 13.0 ) Pub Date : 2003-06-06 , DOI: 10.1016/s1359-6101(03)00023-6
Fabienne Mackay 1 , Christine Ambrose
Affiliation  

B cell activating factor belonging to the TNF family (BAFF) and apoptosis-inducing ligand (APRIL) are two related members of the TNF ligand superfamily. Although they share two receptors, TACI and BCMA, transgenic and knockout mice in this system reveal that their functions are not redundant. BAFF is a critical survival/maturation factor for peripheral B cells and this activity is mediated through a BAFF-specific receptor, BAFF-R. Overexpression of BAFF has been linked to autoimmune disease and aspects of B cell neoplasia. APRIL appears to play a role in T-independent type II antigen responses and T cell survival, but can also induce proliferation/survival of non-lymphoid cells. Elevated expression of APRIL has been found in some tumor cell lines and in tumor tissue libraries. Therapies designed to inhibit the BAFF and APRIL pathways holds great promise for the future.

中文翻译:

TNF家族成员BAFF和APRIL:日益复杂。

属于TNF家族(BAFF)和凋亡诱导配体(APRIL)的B细胞活化因子是TNF配体超家族的两个相关成员。尽管它们共享两个受体,TACI和BCMA,但在该系统中转基因和基因敲除小鼠表明它们的功能并非多余。BAFF是外周B细胞的关键存活/成熟因子,并且该活性通过BAFF特异性受体BAFF-R介导。BAFF的过表达与自身免疫性疾病和B细胞瘤形成有关。APRIL似乎在不依赖T的II型抗原应答和T细胞存活中起作用,但也可以诱导非淋巴细胞的增殖/存活。在一些肿瘤细胞系和肿瘤组织库中发现APRIL的表达升高。
更新日期:2019-11-01
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