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Selective mobilization of fatty acids from adipose tissue triacylglycerols.
Progress in Lipid Research ( IF 13.6 ) Pub Date : 2003-04-12 , DOI: 10.1016/s0163-7827(02)00066-8
Thierry Raclot 1
Affiliation  

Adipose tissue triacylglycerols represent the main storage of a wide spectrum of fatty acids differing by molecular structure. The release of individual fatty acids from adipose tissue is selective according to carbon chain length and unsaturation degree in vitro and in vivo in animal studies and also in humans. The mechanism of selective fatty acid mobilization from white fat cells is not known. Lipolysis is widely reported to work at a lipid-water interface where only small amounts of substrate are available. A preferential hydrolysis of a small triacylglycerol fraction enriched in certain triacylglycerol molecular species at the lipid-water interface and enzymological properties of hormone-sensitive lipase could explain the selective mobilization of fatty acids from fat cells. This selectivity could affect the individual fatty acid supply to tissues.

中文翻译:

从脂肪组织三酰基甘油中选择性动员脂肪酸。

脂肪组织三酰基甘油代表了因分子结构而异的各种脂肪酸的主要存储。在动物研究以及人类中,在体外和体内,根据脂肪链中脂肪的选择性释放是根据碳链长度和不饱和度来进行的。从白色脂肪细胞中选择性脂肪酸动员的机制尚不清楚。据报道,脂解作用可在脂质-水界面上起作用,其中只有少量底物可用。在脂质-水界面上富含某些三酰甘油分子种类的三酰甘油小馏分的优先水解和激素敏感性脂肪酶的酶学性质可以解释脂肪酸从脂肪细胞中的选择性动员。
更新日期:2019-11-01
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