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Protein nitration in cardiovascular diseases.
Pharmacological Reviews ( IF 21.1 ) Pub Date : 2002-11-14 , DOI: 10.1124/pr.54.4.619
Illarion V Turko 1 , Ferid Murad
Affiliation  

There is growing evidence that cardiovascular disease is associated with progressive changes in the production of free radicals and radical-derived reactive species. These intermediates react with all major cellular constituents and may serve several physiological and pathophysiological functions. The nitration of protein tyrosine residues has been used as a footprint for in vivo production of radical and nonradical reactive species. Tyrosine nitration may alter protein function and metabolism and therefore, provides for further dysfunctional changes. This review focuses on an appearance of tyrosine nitrated proteins in cardiovascular tissues under different settings of cardiovascular disease. Sources of reactive species, putative mechanisms of protein nitration in vivo, as well as protein nitration under normal physiological conditions, are also described. The goal of this review is to attract more attention to identification of specific proteins, which undergo tyrosine nitration and to study a correlation between their altered function and pathology. Understanding how protein nitration affects disease progression may offer a unique option for design of antioxidant therapy for the treatment of cardiovascular complications. At the same time, protein nitration can be a biological marker of efficiency of antioxidant therapy.

中文翻译:

心血管疾病中的蛋白质硝化作用。

越来越多的证据表明,心血管疾病与自由基和自由基衍生的反应性物质生产中的进行性变化有关。这些中间体会与所有主要的细胞成分发生反应,并可能具有多种生理和病理生理功能。蛋白酪氨酸残基的硝化已被用作体内产生自由基和非自由基反应物种的足迹。酪氨酸硝化作用可能会改变蛋白质的功能和代谢,因此会导致功能障碍的进一步改变。这篇综述着重于在心血管疾病不同背景下心血管组织中酪氨酸硝酸盐蛋白的出现。反应性物种的来源,体内蛋白质硝化的推测机制以及正常生理条件下的蛋白质硝化,也有描述。这篇综述的目的是吸引更多注意力到酪氨酸硝化的特定蛋白质的鉴定上,并研究其功能改变与病理之间的相关性。了解蛋白质硝化如何影响疾病进展可能为抗氧化剂治疗心血管并发症的治疗设计提供一个独特的选择。同时,蛋白质硝化可以成为抗氧化剂治疗效率的生物学指标。了解蛋白质硝化如何影响疾病进展可能为抗氧化剂治疗心血管并发症的治疗设计提供一个独特的选择。同时,蛋白质硝化可以成为抗氧化剂治疗效率的生物学指标。了解蛋白质硝化如何影响疾病进展可能为抗氧化剂治疗心血管并发症的治疗设计提供一个独特的选择。同时,蛋白质硝化可以成为抗氧化剂治疗效率的生物学指标。
更新日期:2019-11-01
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