Patients with an atrial septal defect (ASD) are at increased risk of developing atrial fibrillation (AF). Currently percutaneous ASD closure is the preferred therapeutic strategy and although pulmonary vein isolation (PVI) for AF is feasible after ASD closure, the transseptal puncture can be technically challenging and probably increases the perioperative risk. A staged approach, with PVI several months before ASD closure, has been recommended for patients already scheduled for closure, but no data are available on combined procedures.

中文翻译：

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伴随肺静脉隔离和经皮闭合房间隔缺损：一个试点项目

房间隔缺损 (ASD) 患者发生心房颤动 (AF) 的风险增加。目前经皮 ASD 封堵是首选的治疗策略，虽然 ASD 封堵后肺静脉隔离 (PVI) 对 AF 是可行的，但经间隔穿刺在技术上可能具有挑战性，并且可能会增加围手术期风险。对于已经计划关闭 ASD 的患者，建议在 ASD 关闭前几个月使用 PVI 的分阶段方法，但没有关于联合程序的数据。