The evolutionarily conserved Notch signalling pathway regulates the differentiation and function of mature T lymphocytes with major context-dependent consequences in host defence, autoimmunity and alloimmunity. The emerging effects of Notch signalling in T cell responses build upon a more established role for Notch in T cell development. Here, we provide a critical review of this burgeoning literature to make sense of what has been learned so far and highlight the experimental strategies that have been most useful in gleaning physiologically relevant information. We outline the functional consequences of Notch signalling in mature T cells in addition to key specific Notch ligand-receptor interactions and downstream molecular signalling pathways. Our goal is to help clarify future directions for this expanding body of work and the best approaches to answer important open questions.

中文翻译：

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T细胞稳态和分化中的Notch信号传导。

进化上保守的Notch信号通路调节成熟T淋巴细胞的分化和功能，在宿主防御，自身免疫和同种免疫中具有重要的背景依赖性。Notch信号在T细胞应答中的新兴作用建立在Notch在T细胞发育中的更确定的作用基础上。在这里，我们对新兴的文献进行了批判性的回顾，以弄清到目前为止所学的知识，并重点介绍在收集生理相关信息方面最有用的实验策略。我们概述了Notch信号在成熟T细胞中的功能后果，以及关键的特定Notch配体-受体相互作用和下游分子信号通路。