Traditional risk factors are incompletely predictive of cardiovascular disease development, a leading cause of death in the elderly. Recent epidemiological studies have shown that human aging is associated with an increased frequency of somatic mutations in the hematopoietic system, which provide a competitive advantage to a mutant cell, thus allowing for its clonal expansion, a phenomenon known as clonal hematopoiesis. Unexpectedly, these mutations have been associated with a higher incidence of cardiovascular disease, suggesting a previously unrecognized connection between somatic mutations in hematopoietic cells and cardiovascular disease. Here, we provide an up-to-date review of clonal hematopoiesis and its association with aging and cardiovascular disease. We also give a detailed report of the experimental studies that have been instrumental in understanding the relationship between clonal hematopoiesis and cardiovascular disease and have shed light on the mechanisms by which hematopoietic somatic mutations contribute to disease pathology.

中文翻译：

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心血管疾病，衰老和克隆性造血。

传统的危险因素不能完全预测心血管疾病的发展，而心血管疾病是老年人死亡的主要原因。最近的流行病学研究表明，人类衰老与造血系统中体细胞突变的频率增加有关，这为突变细胞提供了竞争优势，从而允许其克隆扩增，这种现象被称为克隆性造血。出乎意料的是，这些突变与心血管疾病的发生率更高有关，表明造血细胞的体细胞突变与心血管疾病之间以前未被认识的联系。在这里，我们提供了最新的克隆性造血功能及其与衰老和心血管疾病的关系的综述。