当前位置: X-MOL 学术Emerg. Microbes Infect. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Demographic and clinical characteristics of chikungunya patients from six Colombian cities, 2014-2015.
Emerging Microbes & Infections ( IF 13.2 ) Pub Date : 2019-01-01 , DOI: 10.1080/22221751.2019.1678366
Juan C Rueda 1, 2 , Ana M Santos 2 , Jose-Ignacio Angarita 2 , Rodrigo B Giraldo 2 , Eugenia-Lucia Saldarriaga 2 , Jesús Giovanny Ballesteros Muñoz 3 , Elías Forero 4 , Hugo Valencia 2 , Francisco Somoza 2 , Daniel Martin-Arsanios 2 , Elias-Josué Quintero 2 , Viviana Reyes-Martinez 2 , Diana Padilla 2 , Francy M Cuervo 2 , Ingris Peláez-Ballestas 5 , Mario H Cardiel 6 , Paula X Pavía 7 , John Londono 2, 3
Affiliation  

In 2014, the chikungunya virus reached Colombia for the first time, resulting in a nationwide epidemic. The objective of this study was to describe the demographics and clinical characteristics of suspected chikungunya cases. Chikungunya infection was confirmed by enzyme-linked immunosorbent assay and 548 patients where included in the study. Of these patients, 295 were positive for antibodies against chikungunya (53.8%), and 27.6% (151/295) were symptomatic for chikungunya infection, with a symptomatic:asymptomatic ratio of 1.04:1. Factors associated with infection included low income and low socio-economic strata (odds ratio [OR]: 1.8; 95% confidence interval [CI]: 1.0-3.2, p = 0.003 and OR: 2.1; CI: 1.3-3.4, p = 0.002, respectively). Confirmed symptomatic cases were associated with symmetric arthritis (OR: 11.7; CI: 6.0-23.0, p < 0.001) of ankles (OR: 8.5; CI: 3.5-20.9, p < 0.001), hands (OR: 8.5; CI: 3.5-20.9, p < 0.001), feet (OR: 6.5; CI: 2.8-15.3, p < 0.001), and wrists (OR: 17.3; CI: 2.3-130.5, p < 0.001). Our study showed that poverty is associated with chikungunya infection. Public health strategies to prevent and control chikungunya should focus on poorer communities that are more vulnerable to infection. The rate of asymptomatic infections among confirmed cases was 48.8%. However, those with symptoms displayed a characteristic rheumatic clinical picture, which could help differentiate chikungunya infection from other endemic viral diseases.

中文翻译:

2014-2015 年哥伦比亚六个城市基孔肯雅热患者的人口统计学和临床​​特征。

2014年,基孔肯雅病毒首次传入哥伦比亚,导致全国范围内流行。本研究的目的是描述基孔肯雅热疑似病例的人口统计学和临床​​特征。通过酶联免疫吸附测定证实了基孔肯雅热感染,该研究纳入了 548 名患者。其中,295例基孔肯雅病毒抗体呈阳性(53.8%),27.6%(151/295)有基孔肯雅病毒感染症状,有症状与无症状的比例为1.04:1。与感染相关的因素包括低收入和低社会经济阶层(比值比 [OR]:1.8;95% 置信区间 [CI]:1.0-3.2,p = 0.003 和 OR:2.1;CI:1.3-3.4,p =分别为 0.002)。确诊的有症状病例与踝部(OR:8.5;CI:3.5-20.9,p <0.001)、手部(OR:8.5;CI:3.5)对称性关节炎(OR:11.7;CI:6.0-23.0,p < 0.001)相关。 -20.9,p < 0.001)、脚(OR:6.5;CI:2.8-15.3,p < 0.001)和手腕(OR:17.3;CI:2.3-130.5,p < 0.001)。我们的研究表明贫困与基孔肯雅热感染有关。预防和控制基孔肯雅热的公共卫生战略应重点关注更容易受到感染的贫困社区。确诊病例中无症状感染者率为48.8%。然而,那些有症状的人表现出典型的风湿病临床表现,这可能有助于区分基孔肯雅热感染和其他地方性病毒性疾病。
更新日期:2019-11-01
down
wechat
bug