Nanogels (NGs) are 3‐dimensional (3D) networks composed of hydrophilic or amphiphilic polymer chains, allowing for effective and homogeneous encapsulation of drugs, genes, or imaging agents for biomedical applications. Polyethylenimine (PEI), possessing abundant positively charged amine groups, is an ideal platform for the development of NGs. A variety of effective PEI‐based NGs have been designed and much effort has been devoted to study the relationship between the structure and function of the NGs. In particular, PEI‐based NGs can be prepared either using PEI as the major NG component or using PEI as a crosslinker. This review reports the recent progresses in the design of PEI‐based NGs for gene and drug delivery and for bioimaging applications with a target focus to tackle the diagnosis and therapy of cancer.

中文翻译：

---

用于生物医学的基于聚乙烯亚胺的纳米凝胶。

纳米凝胶（NGs）是由亲水性或两亲性聚合物链组成的3维（3D）网络，可对生物医学应用中的药物，基因或成像剂进行有效且均匀的封装。聚乙烯亚胺（PEI）具有丰富的正电荷胺基，是开发NG的理想平台。已经设计了多种有效的基于PEI的NG，并且已经投入大量精力来研究NG的结构和功能之间的关系。特别是，可以使用PEI作为主要NG组分或使用PEI作为交联剂来制备基于PEI的NG。这篇综述报告了基于PEI的NGs在基因和药物递送以及生物成像应用中的最新进展，其目标重点是解决癌症的诊断和治疗。