The diagnosis of HCL is usually straightforward and is based on the identification of typical HCs in the blood and bone marrow. The suspected diagnosis is confirmed by a combination of TRAP cytochemistry, a distinctive immunophenotype and characteristic BM trephine appearances. Nucleoside treatment is highly effective in inducing prolonged remissions; relapsing patients can usually be successfully retreated with nucleoside. Monoclonal antibody therapy is a promising novel approach to the treatment of resistant disease.

中文翻译：

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毛细胞白血病的诊断和治疗。

HCL的诊断通常很简单，并且基于对血液和骨髓中典型HC的鉴定。结合TRAP细胞化学，独特的免疫表型和特征性的BM色氨酸外观，证实了疑似诊断。核苷治疗在诱导长期缓解方面非常有效；复发的患者通常可以成功地用核苷治疗。单克隆抗体疗法是治疗耐药性疾病的有前途的新方法。