The development of the neuroendocrine hypothalamus has been studied using a variety of neuroanatomical and molecular techniques. Here, the major findings that mold our understanding of hypothalamic development are reviewed. The rat hypothalamus is generated predominantly from the third ventricular neuroepithelium in a "lateral early to medial late" pattern dictated perhaps by the medially receding third ventricle. Neuroendocrine neurons seem to exhibit a delayed migrational strategy, showing relatively early birthdates, although they are located in the latest-generated, periventricular nuclei. Several homeobox genes seem to play a role in hypothalamic development, and gene knockout experiments implicate a number of genes of importance in the generation of the neuroendocrine cell type.

中文翻译：

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神经内分泌下丘脑的发育

已经使用各种神经解剖学和分子技术研究了神经内分泌下丘脑的发育。在这里，回顾了塑造我们对下丘脑发育的理解的主要发现。大鼠下丘脑主要由第三脑室神经上皮以“从外侧早期到内侧晚期”的模式产生，这可能是由内侧后退的第三脑室决定的。神经内分泌神经元似乎表现出延迟迁移策略，显示相对较早的出生日期，尽管它们位于最新生成的脑室周围核中。几个同源盒基因似乎在下丘脑发育中起作用，基因敲除实验暗示了许多在神经内分泌细胞类型的产生中具有重要意义的基因。