Peroxisomes contain enzymes catalyzing a number of indispensable metabolic functions mainly related to lipid metabolism. The importance of peroxisomes in man is stressed by the existence of genetic disorders in which the biogenesis of the organelle is defective, leading to complex developmental and metabolic phenotypes. The purpose of this review is to emphasize some of the recent findings related to the localization of cholesterol biosynthetic enzymes in peroxisomes and to discuss the impairment of cholesterol biosynthesis in peroxisomal deficiency diseases.

中文翻译：

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过氧化物酶体在类异戊二烯生物合成中的核心作用。

过氧化物酶体所含的酶催化许多与脂质代谢有关的必不可少的代谢功能。过氧化物酶体在人类中的重要性被遗传性疾病的存在所强调，在遗传性疾病中细胞器的生物发生是有缺陷的，从而导致复杂的发育和代谢表型。这篇综述的目的是强调与过氧化物酶体中胆固醇生物合成酶的定位有关的一些最新发现，并讨论过氧化物酶体缺乏症疾病中胆固醇生物合成的损害。