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Bisphenol A inhibits penile erection via alteration of histology in the rabbit.
International Journal of Impotence Research ( IF 2.6 ) Pub Date : 2002-03-14 , DOI: 10.1038/sj.ijir.3900734
D G Moon 1 , D J Sung , Y S Kim , J Cheon , J J Kim
Affiliation  

Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative dose of 900 mg/kg). Four and 8 weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals compared to the control animals. Histologically, thickening of tunica albuginea, subtunical deposition of fat and decreased sinusoidal space with consequent increase of trabecular smooth muscle content were observed in the BPA-treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis.

中文翻译:

双酚A通过改变兔的组织学来抑制阴茎勃起。

尽管对双酚A(BPA)的毒性进行了广泛研究,但尚无有关双酚A对勃起功能影响的报道。我们进行了这项研究以调查BPA对勃起功能的影响。每隔一天用150 mg / kg的BPA腹膜内治疗新西兰白兔,持续12天(累计剂量为900 mg / kg)。与对照动物相比,在给予BPA后的第4和第8周,在用BPA治疗的动物中,海绵体组织带的收缩和松弛被显着抑制。组织学上,在用BPA处理过的动物中观察到白膜增厚,亚膜下脂肪沉积和正弦曲线空间减少,从而导致小梁平滑肌含量增加。
更新日期:2019-11-01
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