In this study the prepolymer alpha,omega-bis(4-hydroxybutyl) poly(dimethylsiloxane), used in the formulation of oxygen permeable films, is evaluated by gel permeation chromatography (GPC) combined with matrix assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS). Two unexpected mass distributions are observed in the mass spectra. Reaction schemes for the formation of these distributions are proposed. A solution phase trimethylsilane end group modification was performed on the prepolymer to determine whether the unexpected mass distributions occur as impurities from synthesis or as artifacts from the MS process. Evaluation of the TMS modified prepolymer indicates the unexpected mass distributions indeed occur as impurities from the synthetic procedure. Average molecular weight values are determined by traditional GPC, direct MALDI-TOF MS, and GPC-MALDI-TOF MS methods and the results are compared.

中文翻译：

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使用GPC-MALDI TOF质谱法对α，ω-双（4-羟基丁基）聚（二甲基硅氧烷）进行详细分析。

在这项研究中，通过凝胶渗透色谱法（GPC）结合基质辅助激光解吸电离（MALDI）时间评估了透氧膜配方中使用的预聚物α，ω-双（4-羟丁基）聚（二甲基硅氧烷）。飞行（TOF）质谱（MS）。在质谱图中观察到两个意外的质量分布。提出了形成这些分布的反应方案。在预聚物上进行了溶液相三甲基硅烷端基修饰，以确定出乎意料的质量分布是作为合成中的杂质还是作为MS方法的人工产物出现。对TMS改性预聚物的评估表明，出乎意料的质量分布确实是作为合成过程中的杂质而出现的。