The following sequences have been submitted to the Nomenclature Committee since the April, May and June 2019 nomenclature up‐ date (Marsh, 2019) and, following agreed policy, have been assigned official allele designations (Marsh et al., 2010). Full details of all se‐ quences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and con‐ firmations of previously reported sequences (Table 2). The accession number of each sequence is given, and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent pub‐ lications that describe new HLA sequences is given in Table 3. In addition, the DRB4*01:14 sequence was extended and shown to have a polymorphism in intron 1, causing an alternative splice site prior to exon 2, which prevents translation into a correct and stable class II molecule expressed on the cell surface as such the N suffix has been added, and the name extended to DRB4*01:14N. The al‐ leles A*01:301, A*24:02:01:17, A*24:447, A*24:450, B*18:01:01:12, B*38:68Q, B*44:02:01:13, DRB5*02:26 and DPB1*939:01N have been assessed for their expression status and are now named A*01:301Q, A*24:02:01:17Q, A*24:447Q, A*24:450Q, B*18:01:01:12Q, B*38:68L, B*44:02:01:13Q, DRB5*02:26N and DPB1*939:01, respectively. The sequence for A*24:471 has now been shown to be in error and is identical to A*24:02:01:01; the name A*24:471 has been abandoned. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD‐IMGT/HLA Database using the sequence submission tool provided (Robinson et al., 2015). The IPD‐IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/hla

中文翻译：

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HLA 系统因素的命名法，2019 年 7 月、8 月和 9 月更新

自 2019 年 4 月、5 月和 6 月命名法更新（Marsh，2019 年）以来，以下序列已提交给命名法委员会，并根据商定的政策，分配了官方等位基因名称（Marsh 等人，2010 年）。所有序列的完整细节将在即将发布的报告中公布。下面列出了新分配的序列（表 1）和先前报告序列的确认（表 2）。给出了每个序列的登录号，这些可用于从 EMBL、GenBank 或 DDBJ 数据库中检索序列文件。尽管数据库已经分配了登录号并且大多数序列已经可用，但仍有可能作者尚未允许发布该序列；在这种情况下，您必须直接联系提交作者。有关新序列的附加信息通常包含在描述这些等位基因的出版物中；表 3 列出了描述新 HLA 序列的近期出版物。此外，DRB4*01:14 序列被扩展并显示在内含子 1 中具有多态性，从而导致外显子 2 之前的替代剪接位点，添加了 N 后缀，以防止翻译成正确且稳定的 II 类分子在细胞表面表达，并将名称扩展为 DRB4*01:14N。等位基因 A*01:301, A*24:02:01:17, A*24:447, A*24:450, B*18:01:01:12, B*38:68Q, B* 44:02:01:13、DRB5*02:26 和 DPB1*939:01N 的表达状态已经过评估，现在被命名为 A*01:301Q、A*24:02:01:17Q、A*24： 447Q、A*24:450Q、B*18:01:01:12Q、B*38:68L、B*44:02：分别为 01:13Q、DRB5*02:26N 和 DPB1*939:01。A*24:471 的序列现在已被证明是错误的并且与 A*24:02:01:01 相同；名称 A*24:471 已被放弃。现在，所有新的和验证性序列都应使用提供的序列提交工具通过 IPD-IMGT/HLA 数据库直接提交给 WHO HLA 系统因素命名委员会（Robinson 等，2015）。IPD-IMGT/HLA 数据库可通过万维网访问：www.ebi.ac.uk/ipd/imgt/hla 现在，所有新的和验证性序列都应使用提供的序列提交工具通过 IPD-IMGT/HLA 数据库直接提交给 WHO HLA 系统因素命名委员会（Robinson 等，2015）。IPD-IMGT/HLA 数据库可通过万维网访问：www.ebi.ac.uk/ipd/imgt/hla 现在，所有新的和验证性序列都应使用提供的序列提交工具通过 IPD-IMGT/HLA 数据库直接提交给 WHO HLA 系统因素命名委员会（Robinson 等，2015）。IPD-IMGT/HLA 数据库可通过万维网访问：www.ebi.ac.uk/ipd/imgt/hla