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Impact of circadian rhythms on female reproduction and infertility treatment success.
Current Opinion in Endocrinology, Diabetes and Obesity ( IF 3.2 ) Pub Date : 2019-12-01 , DOI: 10.1097/med.0000000000000511
Jacqueline Mills 1 , Wendy Kuohung
Affiliation  

PURPOSE OF REVIEW In recent years, new studies have investigated the role and influence of sleep on female fertility and early pregnancy outcomes, providing a growing body of knowledge demonstrating how regulation by sleep of hormones are important to reproduction, and how disruptions in sleep, circadian rhythms, and genes regulating circadian rhythmicity can negatively impact fertility and early pregnancy outcomes. This review aims to summarize the most recent research on the relationship among circadian rhythms, fertility, and early pregnancy outcomes in women, and to explore possible fertility interventions. RECENT FINDINGS Recent studies have found altered levels of FSH, LH, and prolactin with sleep disturbance or circadian dysrhythmia. Disruption of circadian rhythms in the form of shift work, jet lag, and daylight savings time changes have been associated with poorer fertility and early pregnancy outcomes. Alterations in the expression of circadian rhythm-regulating circadian locomotor output cycles kaput (CLOCK) genes have been associated with decreased fertility and increased rates of miscarriage. SUMMARY Overall, undisrupted sleep and circadian rhythmicity appear to optimize fertility and early pregnancy outcomes and may play an important role in the success of fertility treatment.

中文翻译:

昼夜节律对女性生殖和不育治疗成功的影响。

综述的目的近年来,新的研究调查了睡眠对女性生育能力和早期妊娠结局的作用和影响,提供了越来越多的知识,证明了激素睡眠调节对生殖至关重要,以及昼夜节律如何影响睡眠节律和调控昼夜节律的基因会对生育能力和早期妊娠结局产生负面影响。这篇综述旨在总结关于昼夜节律,生育力和女性早期妊娠结局之间关系的最新研究,并探讨可能的生育干预措施。最近的发现最近的研究发现,FSH,LH和催乳素水平发生变化,伴有睡眠障碍或昼夜节律不齐。轮班工作,时差,打扰,昼夜节律的破坏,夏令时的改变与生育能力差和早孕结局有关。昼夜节律调节昼夜运动输出周期kaput(CLOCK)基因表达的改变与生育力下降和流产率增加有关。总结总体而言,不间断的睡眠和昼夜节律似乎可以优化生育能力和早期妊娠结局,并可能在生育治疗的成功中发挥重要作用。
更新日期:2019-11-01
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