Hepatic venocclusive disease (VOD) is a common toxicity associated with myeloablative chemotherapy or chemoradiotherapy used to prepare patients for stem cell transplantation. A sizable proportion of patients who develop VOD die. It is clear that injury to endothelial cells and hepatocytes in zone 3 of the liver acinus is the initial event in the pathogenesis of VOD. What are less clear are the mechanisms of injury and whether this knowledge can be exploited. This manuscript will briefly review some recent data and discuss how that information has influenced clinical practice.

中文翻译：

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避免肝静脉阻塞性疾病：我们知道什么，我们要去哪里？

肝静脉阻塞性疾病（VOD）是与清髓化学疗法或化学放疗疗法相关的常见毒性，常用于准备患者进行干细胞移植。大量的VOD患者死亡。显然，对肝腺泡第3区的内皮细胞和肝细胞的损伤是VOD发病机理中的初始事件。尚不清楚伤害的机制以及是否可以利用这些知识。该手稿将简要回顾一些最新数据，并讨论该信息如何影响临床实践。