Protein phosphatase (PP2Calpha) is a member of the mammalian serine threonine-specific protein phosphatases family. We produced monoclonal antibodies against the recombinant PP2Calpha and evaluated the immunoreactivity of normal human tissues. The reactivity was strong in normal skin, the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, while it was moderate in the ovary, testis, and liver. Epithelial cells revealed high levels of PP2Calpha expression, but stromal cells, including fibroblasts and endothelial cells, showed no or little PP2Calpha expression. Given the broad reactivity in endocrine and secreting epithelial cells, we propose that PP2Calpha expression might contribute to secretory cell function.

中文翻译：

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正常人组织中蛋白质磷酸酶2Calpha的表达：一项免疫组织化学研究。

蛋白磷酸酶（PP2Calpha）是哺乳动物丝氨酸苏氨酸特异性蛋白磷酸酶家族的成员。我们生产了针对重组PP2Calpha的单克隆抗体，并评估了正常人组织的免疫反应性。在正常皮肤，消化道，肺，肾，乳腺，前列腺，内分泌腺和脑中反应强烈，而在卵巢，睾丸和肝脏中反应中等。上皮细胞显示出高水平的PP2Calpha表达，但基质细胞（包括成纤维细胞和内皮细胞）却没有或几乎没有PP2Calpha表达。鉴于内分泌和分泌上皮细胞的广泛反应性，我们建议PP2Calpha表达可能有助于分泌细胞功能。