The objective of this study was to examine, using the new WHO criteria for diabetes mellitus, whether insulin and glucose before and after an oral glucose tolerance test would predict cardiovascular mortality in hypertensive men with normal fasting blood glucose. A standard oral glucose challenge was performed after an overnight fast in 113 hypertensive men with either hypercholesterolaemia or smoking. These patients were recruited from an on-going risk factor intervention study. The mean observation time was 6.3 years. During follow-up there were 10 cardiovascular deaths. The Cox regression analyses showed an independent and significant association (P < 0.05) between blood glucose 120 min after the glucose ingestion and cardiovascular death during follow-up. Fasting glucose, fasting insulin and insulin 120 min after glucose ingestion was not related to cardiovascular death during follow-up. In conclusion, this is the first study using the current definition of diabetes mellitus showing that hyperglycaemia following an oral glucose load is an independent risk factor for cardiovascular death in hypertensive men with a normal fasting glucose. In this type of hypertensive patient with normal fasting glucose, an oral glucose tolerance test may help to identify subjects at high cardiovascular risk. Journal of Human Hypertension (2001) 15, 71-74

中文翻译：

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我们应该对空腹血糖正常的高血压男性进行口服葡萄糖耐量测试吗？

这项研究的目的是使用新的WHO糖尿病标准，通过口服葡萄糖耐量试验之前和之后的胰岛素和葡萄糖是否可以预测空腹血糖正常的高血压男性的心血管死亡率。在113名患有高胆固醇血症或吸烟的高血压男性中，禁食过夜后进行了标准的口服葡萄糖激发试验。这些患者是从正在进行的危险因素干预研究中招募的。平均观察时间为6。3年。在随访期间，有10人死于心血管疾病。Cox回归分析显示，摄入葡萄糖120分钟后的血糖与随访期间的心血管死亡之间存在独立且显着的关联（P <0.05）。空腹血糖 空腹胰岛素和葡萄糖摄入后120分钟的胰岛素与随访期间的心血管死亡无关。总之，这是第一个使用当前糖尿病定义的研究，表明口服葡萄糖负荷后高血糖是空腹血糖正常的高血压男性心血管死亡的独立危险因素。在这种类型的空腹血糖正常的高血压患者中，口服葡萄糖耐量试验可能有助于识别心血管疾病高发人群。人类高血压杂志（2001）15，71-74 这是首次使用当前糖尿病定义的研究，表明口服葡萄糖负荷后高血糖是空腹血糖正常的高血压男性心血管死亡的独立危险因素。在这种类型的空腹血糖正常的高血压患者中，口服葡萄糖耐量试验可能有助于识别心血管疾病高发人群。人类高血压杂志（2001）15，71-74 这是首次使用当前糖尿病定义的研究，表明口服葡萄糖负荷后高血糖是空腹血糖正常的高血压男性心血管死亡的独立危险因素。在这种类型的空腹血糖正常的高血压患者中，口服葡萄糖耐量试验可能有助于识别心血管疾病高发人群。人类高血压杂志（2001）15，71-74