Coronary artery disease (CAD) and ischemic stroke (IS) are commonly considered distinct disease phenotypes. However, there is some evidence in favor of a degree of overlap between genetic susceptibility to CAD and genetic risk factors for IS. In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population. The sample size was 400, and the methodology for SNP genotyping was ARMS-PCR. Both SNPs showed strong associations with CAD in the analyses comparing significant CAD and myocardial infarction (MI) with controls. None of them, however, were associated with MI in patients with significant CAD. Our findings further support the role of the ADAMTS7 locus in promoting atherosclerosis in LAs of the brain. Regarding ZC3HC1 rs11556924, our study further supports the observed association of rs11556924 with LA IS coming from previous GWASs. In conclusion, the data showed that common variants in ADAMTS7 and ZC3HC1 genes contribute to an increased risk for both CAD and LA (atherosclerotic) IS.

中文翻译：

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ADAMTS7和ZC3HC1在冠状动脉疾病和大动脉缺血性卒中中具有遗传易感性。

冠状动脉疾病（CAD）和缺血性中风（IS）通常被认为是不同的疾病表型。但是，有一些证据表明对CAD的遗传易感性与IS的遗传危险因素之间存在一定程度的重叠。在本研究中，我们旨在研究分别位于ADAMTS7和ZC3HC1基因中的两个单核苷酸多态性（SNP）rs3825807和rs11556924的作用，这些基因与CAD在欧洲人群中的GWAS中相关联，以及它们可能对伊朗人群的病例对照研究显示冠状动脉粥样硬化和脑LA动脉粥样硬化的发展。样本大小为400，SNP基因分型的方法为ARMS-PCR。在将显着的CAD和心肌梗塞（MI）与对照进行比较的分析中，两个SNP均显示出与CAD的强相关性。然而，在CAD显着的患者中，它们均与MI无关。我们的发现进一步支持ADAMTS7基因座在促进大脑LA动脉粥样硬化中的作用。关于ZC3HC1 rs11556924，我们的研究进一步支持了已观察到的rs11556924与以前的GWAS的LA IS的关联。总之，数据表明，ADAMTS7和ZC3HC1基因的常见变异会增加CAD和LA（动脉粥样硬化）IS的风险。我们的研究进一步支持观察到的rs11556924与来自先前GWAS的LA IS的关联。总之，数据表明，ADAMTS7和ZC3HC1基因的常见变异会增加CAD和LA（动脉粥样硬化）IS的风险。我们的研究进一步支持观察到的rs11556924与来自先前GWAS的LA IS的关联。总之，数据表明，ADAMTS7和ZC3HC1基因的常见变异会增加CAD和LA（动脉粥样硬化）IS的风险。