Ras-associated protein 1(Rap1) is a member of the RAS family of small G proteins and regulates several signal pathways involved in carcinogenesis. Rap1 consists of two highly homologous isoforms, Rap1a and Rap1b. Increasing data suggest that the deregulated activation of Rap1b is involved in a spectrum of malignancies. Accumulating evidence also indicates effects of Rap1b on cell proliferation, metastasis, angiogenesis, and treatment resistance. Rap1b overexpresses in many tumors and has prognostic values, which are regulated by A2br, miRNAs, and other upstream effectors. This article aims to review research progress in function, significance, and regulation of Rap1b in malignancy.

中文翻译：

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Rap1b在恶性肿瘤中的功能，意义和调控。

Ras相关蛋白1（Rap1）是小G蛋白RAS家族的成员，并调节与癌变有关的几种信号途径。Rap1由两个高度同源的同工型Rap1a和Rap1b组成。越来越多的数据表明，Rap1b的失活激活与一系列恶性肿瘤有关。越来越多的证据还表明Rap1b对细胞增殖，转移，血管生成和治疗耐药性有影响。Rap1b在许多肿瘤中过表达，并具有预后价值，这受A2br，miRNA和其他上游效应子调控。本文旨在综述Rap1b在恶性肿瘤中的功能，意义和调控研究进展。