Hepatocellular carcinoma is the sixth most common liver cancer worldwide and the third leading cause of cancer mortality. For these reasons, early diagnostic, prognostic, and therapeutic biomarkers are extremely urgent. MicroRNAs are small noncoding single-stranded RNA molecules that are reported to be involved in a variety of physiological and pathological processes during carcinogenesis. In this study, the expression characteristics, functions, and validated targets of microRNAs in HCC were summarized and potential microRNA biomarkers were confirmed from clinical specimens. Multiple-scales integrative analysis was used to predict the diagnostic, prognostic, and therapeutic potential of microRNAs in blood and tissue of HCC patients, providing novel insight into HCC diagnosis and treatment using microRNA biomarkers.

中文翻译：

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MicroRNA的多尺度综合分析揭示了肝细胞癌的生物标志物和关键调控联系。

肝细胞癌是全球第六大最常见的肝癌，也是癌症死亡率的第三大主要原因。由于这些原因，早期诊断，预后和治疗性生物标记非常迫切。MicroRNA是小的非编码单链RNA分子，据报道在致癌过程中涉及多种生理和病理过程。在这项研究中，总结了肝癌中microRNA的表达特征，功能和经过验证的靶标，并从临床标本中确认了潜在的microRNA生物标志物。多尺度综合分析用于预测HCC患者血液和组织中microRNA的诊断，预后和治疗潜力，从而为使用microRNA生物标记物进行HCC诊断和治疗提供新的见解。