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Early reversal of ketamine/dexmedetomidine chemical immobilization by atipamezole in golden-headed lion tamarins (Leontopithecus chrysomelas).
Journal of Medical Primatology ( IF 0.7 ) Pub Date : 2019-06-13 , DOI: 10.1111/jmp.12429
Mario A R Ferraro 1 , Camila V Molina 2 , Vanessa N Gris 1 , Maria C M Kierulff 3, 4 , Marina Galvão Bueno 5 , Silvia R G Cortopassi 1
Affiliation  

BACKGROUND A smooth and rapid recovery from anesthesia allowing safe release is desirable, especially for wild species. This study describes the clinical effects of the combination of dexmedetomidine and ketamine and the partial reversal with atipamezole in golden-headed lion tamarins. METHODS Dexmedetomidine 10 μg kg-1 and ketamine 15 mg kg-1 were administered to 45 golden-headed lion tamarins undergoing vasectomy. Following surgery, animals were assigned to three groups: control (SAL; 0.9% NaCl), atipamezole 20 μg kg-1 (ATI20), and atipamezole 40 μg kg-1 (ATI40). RESULTS AND CONCLUSIONS All animals presented great scores of sedation and muscle relaxation during the procedure. Recovery in the control group was smooth and uneventful. Salivation, muscle tremors, and head movements were observed in ATI 20 and ATI40. The administration of atipamezole did not change total recovery times (ATI20 69 ± 23 minutes; ATI40 72 ± 45 minutes; SAL 57 ± 23 minutes).

中文翻译:

在金头狮子猴(Leontopithecus chrysomelas)中由atipamezole进行的氯胺酮/右美托咪定化学固定的早期逆转。

背景技术从麻醉中平稳且快速地恢复以允许安全释放是期望的,特别是对于野生物种。这项研究描述了右美托咪定和氯胺酮的组合以及金头狮猴的部分逆转与阿替哌唑的临床效果。方法对45例输精管结扎的金头狮子绢毛猴给予右美托咪啶10μgkg-1和氯胺酮15 mg kg-1。手术后,将动物分为三组:对照组(SAL; 0.9%NaCl),阿替哌唑20μgkg-1(ATI20)和阿替哌唑40μgkg-1(ATI40)。结果与结论在手术过程中,所有动物均表现出很大的镇静作用和肌肉松弛。对照组的恢复平稳而平稳。在ATI 20和ATI40中观察到流涎,肌肉震颤和头部运动。
更新日期:2019-11-01
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