In this paper, a dual-biomarker-based neural sensing and conditioning device is proposed for closing the feedback loop in deep brain stimulation devices. The device explores both local field potentials (LFPs) and action potentials (APs) as measured biomarkers. It includes two channels, each having four main parts: (1) a pre-amplifier with built-in low-pass filter, (2) a ground shifting circuit, (3) an amplifier with low-pass function, and (4) a high-pass filter. The design specifications include miniature-size, light-weight, and 100 dB gain in the LFP and AP channels. This device has been validated through bench and in-vitro tests. The bench tests have been performed using different sinusoidal signals and pre-recorded neural signals. The in-vitro tests have been conducted in the saline solution that mimics the brain environment. The total weight of the device including a 3 V coin battery, and battery holder is 1.2 g. The diameter of the device is 11.2 mm. The device can be used to concurrently sense LFPs and APs for closing the feedback loop in closed-loop deep brain stimulation systems. It provides a tetherless head-mountable platform suitable for pre-clinical trials.

中文翻译：

---

一种用于闭环 DBS 的基于双生物标志物的微型传感和调节装置

在本文中，提出了一种基于双生物标志物的神经传感和调节装置，用于关闭深部脑刺激装置中的反馈回路。该设备探索局部场电位 (LFP) 和动作电位 (AP) 作为测量的生物标志物。它包括两个通道，每个通道有四个主要部分：(1) 内置低通滤波器的前置放大器，(2) 接地移位电路，(3) 具有低通功能的放大器，以及 (4)一个高通滤波器。设计规格包括小型、轻量和 LFP 和 AP 通道中的 100 dB 增益。该设备已通过台架和体外测试验证。已经使用不同的正弦信号和预先记录的神经信号进行了台架测试。体外测试是在模拟大脑环境的盐水溶液中进行的。包括 3 V 纽扣电池和电池座在内的设备总重量为 1.2 克。该装置的直径为 11.2 毫米。该设备可用于同时感测 LFP 和 AP，以关闭闭环深部脑刺激系统中的反馈回路。它提供了适用于临床前试验的无绳头戴式平台。