Background

In recent years, the high mobility group box-1 (HMGB1) protein, a damage-associated molecular pattern (DAMP) molecule, has been found to play multifunctional roles in the pathogenesis of colorectal cancer. Although much attention has been given to the diagnostic and prognostic values of HMGB1 in colorectal cancer, the exact functional roles of the protein as well as the mechanistic pathways involved have remained poorly defined. This systematic review aims to discuss what is currently known about the roles of HMGB1 in colorectal cancer development, growth and progression, and to highlight critical areas for future investigations. To achieve this, the bibliographic databases Pubmed, Scopus, Web of Science and ScienceDirect were systematically screened for articles from inception till June 2018, which address associations of HMGB1 with colorectal cancer.

Conclusions

HMGB1 plays multiple roles in promoting the pathogenesis of colorectal cancer, despite a few contradicting studies. HMGB1 may differentially regulate disease-related processes, depending on the redox status of the protein in colorectal cancer. Binding of HMGB1 to various protein partners may alter the impact of HMGB1 on disease progression. As HMGB1 is heavily implicated in the pathogenesis of colorectal cancer, it is crucial to further improve our understanding of the functional roles of HMGB1 not only in colorectal cancer, but ultimately in all types of cancers.

中文翻译：

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HMGB1：其在大肠癌发病机理中的多种作用的概述。

背景

近年来，已经发现高迁移率族box-1（HMGB1）蛋白是一种损伤相关分子模式（DAMP）分子，在结直肠癌的发病机理中起着多功能的作用。尽管人们已经高度关注HMGB1在结直肠癌中的诊断和预后价值，但该蛋白的确切功能作用以及所涉及的机制途径仍知之甚少。这篇系统的综述旨在讨论关于HMGB1在结直肠癌的发生，发展和进展中的作用的当前已知信息，并着重指出未来研究的关键领域。为此，系统地筛选了书目数据库Pubmed，Scopus，Web of Science和ScienceDirect从成立到2018年6月的文章，

结论

尽管有一些相互矛盾的研究，HMGB1在促进结直肠癌的发病机理中起着多种作用。HMGB1可能会差异调节疾病相关的过程，具体取决于大肠癌中蛋白质的氧化还原状态。HMGB1与各种蛋白质伴侣的结合可能会改变HMGB1对疾病进展的影响。由于HMGB1与结直肠癌的发病机理密切相关，因此进一步提高我们对HMGB1的功能作用的理解不仅对结直肠癌，而且最终在所有类型的癌症中至关重要。